Irbesartan/Hctz Online



How and where to order Irbesartan with Hydrochlorothiazide (Avalide) 150 mg / 12.5 mg tablets or capsules online on the National Board of Anesthesiology, Inc. website:

Shop:DFH PHARMACY
Stores:PHARMA DOCTOR
Prices:from $1.11 per pill
Discount:10% coupon: DFH10
Forms:Avalide (Irbesartan, Hctz) 150 mg / 12.5 mg tablets
Quantity:30-270 pills
Type:Irbesartan/HCT brand, Avalide generic
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Irbesartan with Hydrochlorothiazide (trade names include Avalide, Aprozide, Avapro HCT, CoAprovel, Irbesartan HCTZ, Irovel-H, Teva-Irbesartan HCTZ, Karvezide, Sandoz Irbesartan HCT) is a combined medication containing antihypertensive drug Irbesartan (from angiotensin II antagonists) and diuretic Hydrochlorothiazide (from thiazides pharmacological group). This medicine is used for the treatment of high blood pressure (hypertension). It helps to prevent strokes, heart attacks, kidney problems. Irbesartan works by relaxing the blood vessels. Hydrochlorothiazide helps the kidneys to remove fluid from the body.


Avalide (Irbesartan, Hydrochlorothiazide) logo


Related medications:

  • Amlodipine (Norvasc)
  • Atenolol (Tenormin)
  • Azilsartan (Edarbi)
  • Bisoprolol (Zebeta)
  • Candesartan (Atacand, Blopress)
  • Diltiazem (Cardizem, Cartia)
  • Enalapril (Vasotec)
  • Eprosartan (Teveten)
  • Hydrochlorothiazide, Losartan (Hyzaar)
  • Hydrochlorothiazide, Olmesartan (Benicar HCT)
  • Hydrochlorothiazide, Telmisartan (Micardis HCT)
  • Hydrochlorothiazide, Valsartan (Diovan HCT)
  • Indapamide (Lozol)
  • Irbesartan (Avapro)
  • Labetalol (Trandate)
  • Losartan (Cozaar)
  • Metoprolol (Lopressor, Toprol XL)
  • Nifedipine (Adalat)
  • Olmesartan (Benicar)
  • Propranolol (Inderal)
  • Tasosartan (Verdia)
  • Telmisartan (Micardis)
  • Terazosin (Hytrin)
  • Valsartan (Diovan)
  • Verapamil (Calan)


    Pharmacological and medical categories:

  • Angiotensin II receptor antagonists
  • Antihypertensive drugs
  • Cardiovascular medications
  • Combined antihypertensive medicines
  • Thiazide diuretics with angiotensin II receptor antagonists


    ATC codes:

  • C - Cardiovascular system
  • C09 - Agents acting on the renin-angiotensin system
  • C09D - Angiotensin II receptor blockers (ARBS), combinations
  • C09DA - Angiotensin II receptor blockers (ARBs) and diuretics
  • C09DA04 - Irbesartan and diuretics


    ICD-10 codes:

  • Essential (primary) hypertension - I10
  • Acute myocardial infarction - I21
  • Complications and ill-defined descriptions of heart disease - I51


    Indications and usage:

    Avalide is a combination of irbesartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic, indicated for hypertension:

  • In patients not adequately controlled with monotherapy.
  • As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goals.


    Dosage and administration:

    General considerations

  • Maximum effects within 2 to 4 weeks after dose change.
  • Renal impairment: not recommended for patients with severe renal impairment (creatinine clearance < 30 mL/min).

    Hypertension

  • Initiate with 150/12.5 mg. Titrate to 300/12.5 mg then 300/25 mg if needed.
  • Replacement therapy: may be substituted for titrated components.


    Dosage forms and strengt:

    Avalide tablets containing:

  • 75 mg irbesartan and 12.5 mg hydrochlorothiazide.
  • 150 mg irbesartan and 12.5 mg hydrochlorothiazide.
  • 300 mg irbesartan and 12.5 mg hydrochlorothiazide.
  • 300 mg irbesartan and 25 mg hydrochlorothiazide.


    Overdosage:

    Irbesartan

    No data are available in regard to overdosage in humans. However, daily doses of 900 mg for 8 weeks were well tolerated. The most likely manifestations of overdosage are expected to be hypotension and tachycardia; bradycardia might also occur from overdose.

    Irbesartan is not removed by hemodialysis.

    To obtain up-to-date information about the treatment of overdosage, a good resource is a certified regional Poison Control Center. In managing overdose, consider the possibilities of multiple-drug interactions, drug-drug interactions, and unusual drug kinetics in the patient.

    Laboratory determinations of serum levels of irbesartan are not widely available, and such determinations have, in any event, no established role in the management of irbesartan overdose.

    Acute oral toxicity studies with irbesartan in mice and rats indicated acute lethal doses were in excess of 2000 mg/kg, about 25-fold and 50-fold the MRHD (300 mg) based on body surface area.

    Hydrochlorothiazide

    The most common signs and symptoms of overdose observed in humans are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in both mice and rats.


    Contraindications:

  • Hypersensitivity to any component of this product.
  • Anuria.
  • Hypersensitivity to sulfonamide-derived drugs.
  • Do not coadminister aliskiren with Avalide in patients with diabetes.


    Warnings and precautions:

  • Hypotension: correct volume depletion prior to administration of Avalide.
  • Impaired renal function.
  • Thiazide diuretics may cause an exacerbation or activation of systemic lupuserythematosus.
  • Acute angle-closure glaucoma, acute myopia, and choroidal effusion.


    Adverse reactions, side effects:

    Most common adverse events ( >= 5% on combined irbesartan with hydrochlorothiazide pills and more often than on placebo) are dizziness, fatigue, and musculoskeletal pain.

    To report suspected side effects of Avalide (Irbesartan, Hctz) tablets contact Sanofi pharmaceutical company or your local FDA.


    Drug interactions:

  • NSAIDs and selective COX-2 inhibitors: can reduce diuretic, natriuretic of diuretic, may lead to increased risk of renal impairment and reduced antihypertensive effect. Monitor renal function periodically.
  • Dual blockade of the renin-angiotensin system: increased risk of renal impairment, hypotension, and hyperkalemia.
  • Antidiabetic drugs: dosage adjustment of antidiabetic may be required.
  • Cholestyramine and colestipol: reduced absorption of thiazides.
  • Lithium: increases in serum lithium concentrations and lithium toxicity.
  • Carbamazepine: increased risk of hyponatremia.


    Use in specific populations:

    Lactation: potential for adverse effects in infant.


    Patient counseling information:

    Pregnancy

    Tell female patients of childbearing age about the consequences of exposure to Avalide (Irbesartan, Hydrochlorothiazide) during pregnancy. Discuss treatment options with women planning to become pregnant. Ask patients to report pregnancies to their physician as soon as possible.

    Symptomatic hypotension

    Tell patients using Avalide that they may feel lightheaded, especially during the first days of use. Tell patients to inform their physician if they feel lightheaded or faint. Tell the patient, if fainting occurs, stop using this medication and contact the prescribing doctor.

    Tell patients using Irbesartan/Hctz tablets that getting dehydrated can lower their blood pressure too much and lead to lightheadedness and possible fainting. Dehydration may occur with excessive sweating, diarrhea, or vomiting and with not drinking enough liquids.

    Potassium supplements

    Advise patients not to use potassium supplements or salt substitutes containing potassium without consulting their healthcare provider.

    Acute angle-closure glaucoma, acute myopia, and choroidal effusion

    Advise patients to discontinue Avalide and seek immediate medical attention if they experience symptoms of acute angle-closure glaucoma, acute myopia, and choroidal effusion.

    Non-melanoma skin cancer

    Instruct patients taking hydrochlorothiazide to protect skin from the sun and undergo regular skin cancer screening.


    Pregnancy categories:

  • D - Australia
  • D - United States (Positive evidence of risk)


    Salts and other forms:

  • Irbesartan Base
  • Irbesartan Hydrochloride Sesquihydrate
  • Hydrochlorothiazide Base
  • Hydrochlorothiazide Hydrochloride


    Synonyms of irbesartan, international and chemical names:

  • Irbesartane
  • Irbesartanum
  • Irbezartan
  • Irbisartan
  • Chlorsulfonamidodihydrobenzothiadiazine Dioxide
  • Clorhidrato Hidroclorotiazida
  • Dihydrochlorothiazid
  • Dihydrochlorothiazide


    Synonyms of hydrochlorothiazide, international and chemical names:

  • HCTZ
  • HCZ
  • Hidrochlortiazid
  • Hidroclorotiazida
  • Hidrohlorotiazid
  • Hydrochloorthiazide
  • Hydrochlorothiazid
  • Hydrochlorothiazidum
  • Hydrochlorthiazide
  • Hydrochlorthiazidum
  • Hydroklooritiatsidi
  • Hydroklortiazid
  • Idroclorotiazide


    Brands, generics, trade names:

  • Aprovel HCT - Sanofi
  • Aprozide - Sanofi, The Harvard Drug Group
  • Avalide - Sanofi
  • Avapro HCT - Bristol-Myers Squibb
  • CoAprovel - Sanofi
  • Irbesartan HCT - Actavis, Sandoz
  • Irbesartan HCTZ - Pro Doc, Sanis Health
  • Irbesartan, Hydrochlorothiazide - Mylan, Sandoz, Teva, Zydus Pharmaceuticals
  • Irovel-H - Sun Pharmaceutical Industries
  • Irtan Plus - Ikapharmindo Putramas
  • Karvezide - Bristol-Myers Squibb
  • PMS-Irbesartan-Hctz - Pharmascience
  • Sandoz Irbesartan HCT - Sandoz
  • Teva-Irbesartan HCTZ - Teva


    Here is a list of popular medications containing irbesartan with hydrochlorothiazide as main active pharmaceutical ingredients; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Avalide
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 75 mg
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Tablets; Oral; Hydrochlorothiazide 25 mg; Irbesartan 300 mg
  • Sanofi
  • Bristol-Myers Squibb
  • Avapro HCT
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Bristol-Myers Squibb
  • CoAprovel
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 25 mg; Irbesartan 150 mg
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 25 mg; Irbesartan 300 mg
  • Sanofi
  • Bristol-Myers Squibb
  • DKSH
  • IDS Group
  • Metro Drug Distribution
  • The Glory Medicina
  • Zuellig Pharma
  • Co-Irbesartan
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 25 mg; Irbesartan 300 mg
  • Sandoz
  • Irbesartan HCT
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets, Film-Coated; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Actavis
  • Irbesartan HCTZ
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Tablets; Oral; Hydrochlorothiazide 25 mg; Irbesartan 300 mg
  • Pro Doc
  • Irovel-H
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Sun Pharmaceutical Industries
  • Sin Byu Gyun Trading
  • Karvezide
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 150 mg
  • Tablets; Oral; Hydrochlorothiazide 12.5 mg; Irbesartan 300 mg
  • Bristol-Myers Squibb
  • Lek
  • Sanofi



  • References:

  • Irbesartan main article on Wikipedia: https://en.wikipedia.org/wiki/Irbesartan
  • Hydrochlorothiazide main article on Wikipedia: https://en.wikipedia.org/wiki/Hydrochlorothiazide
  • Irbesartan compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Irbesartan
  • Hydrochlorothiazide compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/3639
  • Irbesartan medication on DrugBank: https://go.drugbank.com/drugs/DB01029
  • Hydrochlorothiazide medicine on DrugBank: https://go.drugbank.com/drugs/DB00999
  • Irbesartan FAQ on MedlinePlus (revised 01/15/2018): https://medlineplus.gov/druginfo/meds/a698009.html
  • Hydrochlorothiazide FAQ on MedlinePlus (revised 02/15/2021): https://medlineplus.gov/druginfo/meds/a682571.html
  • AvKARE Irbesartan and Hydrochlorothiazide tablets film-coated drug label on DailyMed (revised July 13, 2021): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Avalide (Irbesartan and Hydrochlorothiazide) tablets film-coated drug label on DailyMed (revised November 16, 2021): https://dailymed.nlm.nih.gov/dailymed/lookup...
  • Irbesartan containing drugs on Drugs-About.com: https://drugs-about.com/ing/irbesartan.html
  • Hydrochlorothiazide containing drugs on Drugs-About.com: https://drugs-about.com/ing/hydrochlorothiazide.html
  • Hydrochlorothiazide with Irbesartan for sale on Pharma Doctor (revised December 2021): https://pharma-doctor.com/hydrochlorothiazide-irbesartan.html
  • Avalide (Irbesartan/Hctz) 150/12.5 mg, 300/12.5 mg tablets for oral use official prescribing and patient counseling information from the U.S. FDA (revised 02/2015): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Avalide (Hydrochlorothiazide and Irbesartan) tablets prescribing information from Sanofi pharmaceutical company (revised 09/2021): https://products.sanofi.us/avalide/avalide.pdf
  • Avapro HCT (Irbesartan, Hydrochlorothiazide) tablets consumer medicine information from NPS MedicineWise (revised June 2020): https://www.nps.org.au/assets/medicines/...
  • CoAprovel (Irbesartan, Hydrochlorothiazide) tablets product information and package leaflet for patients from European Medicines Agency: https://www.ema.europa.eu/en/documents/...
  • Irbesartan/HCT Sandoz tablets product information from The Therapeutic Goods Administration (revised 30/08/2021): https://www.ebs.tga.gov.au/ebs/picmi/...
  • Irbesartan Hctz MLabs tablets product information from The Therapeutic Goods Administration (revised 22/02/2021): https://www.ebs.tga.gov.au/ebs/picmi/...
  • Karvezide (Irbesartan & Hydrochlorothiazide) tablets consumer medicine information from NPS MedicineWise (revised November 2019): https://www.nps.org.au/assets/medicines/...
  • CoAprovel (Irbesartan, Hydrochlorothiazide) 150 mg / 12.5 mg film-coated tablets package information leaflet on Medicines.org.uk (revised March 2021): https://www.medicines.org.uk/emc/files/pil.4112.pdf

    Revised: December 2021



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